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Heart Health: 5 Everyday Medications That Silently Cause Arterial Blockage


Some common medicines may harm your arteries. Know about 5 everyday drugs that silently cause arterial blockage and increase heart risk.

Heart Health: 5 Everyday Medications That Silently Cause Arterial Blockage



Written by Muskan Gupta |Published : October 11, 2025 1:10 PM IST

Most of us are concerned about the diet, exercise, and lifestyle habits as far as heart health is concerned.But did you realise, that you may have some sort of medication, which you do take each day is quietly influencing your arteries? Artery blockage is a primary risk factor in heart attacks and strokes; some drugs may occasionally make the arteries even more blocked, particularly over the long run or without close supervision. Being aware about such drugs can enable you to make right decisions concerning your physician.

5 Everyday Medications That Silently Cause Arterial Blockage

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

The most commonly used medications to cure pain, inflammation and fever are NSAIDs, which include ibuprofen, naproxen and over-the-counter painkillers. Even though effective, frequent and chronic consumption of these medications can predispose one to heart problems. NSAIDs have the capability of causing inflammation of blood vessels and increasing blood pressure, which contributes to the accumulation of plaque in blood arteries with passing time.

Certain Birth Control Pills

Oral birth control pills, especially those containing oestrogen in high doses, are identified as having moderately high odds of causing blood clots. Blockage of the arteries may be caused by these clots, particularly in those women having other predisposing factors like high blood pressure or smoking.

Some Diabetes Medications

Some of the older diabetes medications, such as some of the sulfonylureas, have the potential to harm cardiovascular wellbeing. They will be one of the contributors to weight gain and insulin resistance or other metabolic alterations indirectly predisposing the risk of atherosclerosis (hardening of the arteries).

Proton Pump Inhibitors (PPIs)

In some studies, the use has been strictly shown to increase the risk of heart attack when used long-term. The PPIs have the potential to suppress the manufacture of nitric oxide in blood vessels, which is one molecule in blood vessels that allows them to remain flexible and in a healthy condition. Rigid arteries have higher chances of accumulating plaque, hence possible obstructions.

Certain Antidepressants

There are some tricyclic antidepressants, as well as high-dose selective serotonin reuptake inhibitors (SSRI), that cause side effects that impact the cardiovascular system. They are able to raise blood pressure, boost the heart rate or make one gain weight- all factors that are risk contributors to the accumulated plaque in the arteries.

Disclaimer: The content on TheHealthSite.com is for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a health expert.



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